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Low GABA levels in the brain have been implicated in epilepsy and several other neurological diseases.
In addition to its role in cancer, the GATOR complex has also been implicated in epilepsy (10).
This review summarizes the models for studying astrocytic Ca2+ dynamics and the consequential Ca2+-dependent glutamate release, which plays a role in astrocytic-neuronal signaling and have been implicated in epilepsy.
The gene's mutated isoforms have been implicated in epilepsy [31] and, as a subunit of the type A GABA receptor, this gene is part of a protein complex heavily targeted by pharmaceuticals.
Remarkably, Wnt signaling which is the most significant pathway in our analysis has previously been implicated in epilepsy [ 48].
Indeed, the GABA transporters have been implicated in epilepsy (3), and one isoform (GAT1) is the target of the anti-epileptic drug tiagabine (7, 8).
Similar(52)
Located on chromosome 8, both are associated with cancer, and one, which is expressed in the brain, is implicated in epilepsy.
Two of the nine genes that show allelic exclusion are implicated in epilepsy, some subtypes of which show both twin discordance and phenotypic variability.
Another important point to be taken away from the next-generation sequencing experiments is the diverse classes of genes that are emerging as being implicated in epilepsy.
For instance, RasGRF1 regulates learning and memory and is implicated in epilepsy, striatum-dependent motor behavioral deficits induced by cocaine, L-dopa, or amphetamine [ 107– 107].
But Julius and his colleagues used compounds that selectively block each sodium channel subtype to establish that Hm1a acts on the Nav1.1 channel, which has previously been implicated in autism, epilepsy, and Alzheimer's Disease, but not in pain.
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been implicated in plaque
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been implicated in insulin
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been documented in epilepsy
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been investigated in epilepsy
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