Because caveolae have been implicated in the entry of microbial pathogens, we examined their role in the entry of Salmonella typhimurium into host cells as this bacterium enters the eukaryotic host cell and replicates therein.
Although several molecules have already been implicated in the entry process of HCV, it is likely that additional specific factors regulate its entry into hepatic cells [41].
RAB5 is a major player in both these entry mechanisms and functions in subsequent steps required for bacteria replication., ABL kinases have also been implicated in the entry of invasive bacteria.
Similarly, CD81 has been implicated in the entry of HCV into its natural host cells [22].
In mice, retinoic acid (RA) signaling has been implicated in controlling entry into meiosis in germ cells, as meiosis in male embryonic germ cells is blocked by the activity of a RA-catabolizing enzyme, CYP26B1.
While Aurora B has been implicated in mitotic entry and also in cytokinesis and mitotic exit, the primary role for this kinase is in the assembly of factors involved in spindle attachment and tension and regulation of the mitotic checkpoint.
8– 12 Interestingly, STIM1 has also been reported to activate TRPC1, 13, 14 a member of the transient receptor potential (TRP) family of proteins which have been implicated in cation entry.
These specialized domains have been implicated in the entry of a variety of pathogens (Lafont et al., 2004; Lafont and Van Der Goot, 2005; Pietiäinen et al., 2005; Zaas et al., 2005).
Integrins and heparan sulfate have been implicated in KSHV cell entry via interaction with KSHV glycoproteins.
CMV gB has been implicated in host cell entry, cell-to-cell viral transmission and fusion of infected cells [ 2- 4].
