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From a previous publication, rotenone has been implicated in enhancing the NADPH oxidase in microglial cells of the brain with enhanced release into the extracellular space with subsequent neuron degeneration (Gao et al, 2003).
Brain-derived neurotrophic factor (BDNF) has been implicated in enhancing neuronal health.
Like PERK, IRE1 signaling has also been implicated in enhancing or impairing cell survival.
Although the amount of surface GRP78 represents only a very small fraction of cellular GRP78, it has been implicated in enhancing mitogenic signaling, proliferation and cell survival [15], [17], [36] [40].
The overexpression of EGFRvIII has been implicated in enhancing the tumorigenicity and resistance to radiation and chemotherapy in GBM.
The kindlin-binding protein, ILK, has also been implicated in enhancing clustering and the connection to the cytoskeleton.
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Generation of autoantibodies in RA could therefore be implicated in enhancing atherosclerotic events in patients suffering with this disease.
Certain physiological functions of ex-NMDAR are implicated in enhancing synaptic signaling and temporal coordination of synaptic firing.
ROS may be implicated in enhancing P2X7R potency on MDSCs themselves by an autocrine loop and on a P2X7R+ adjacent cells in a paracrine manner.
Increased Brn-3b expression via growth factors such as NGF and EGF or the hormone, estradiol, which are implicated in enhancing the growth of breast cancer cells, are likely to be are propagated by autoregulation.
Genetic variation is implicated in enhancing the division of labor in honey bee colonies [ 15] but not expected to result from selection on worker ovary size per se [ 16].
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