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The PDGF has been implicated in endothelial cell dysfunction and proliferation and migration of smooth muscle cells [ 67, 68].
Adipocytes produce adipokines known to affect endothelial cell function and have therefore also been implicated in endothelial cell dysfunction [ 51].
Of note, an excessive production of ROS has been implicated in endothelial inflammatory activation and the pathogenesis of atherosclerosis [ 31].
Excess generation of ROS and oxidative stress has been implicated in endothelial dysfunction through the inactivation of NO.
This phenomenon, referred to as eNOS uncoupling, has been implicated in endothelial dysfunction associated with a variety of cardiovascular diseases including atherosclerosis, hypertension and diabetes [2 4].
Cytokines and chemokines are considered to be immunological markers and have been implicated in endothelial dysfunction and subsequent vascular abnormalities (30).
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A cellular protein that is implicated in endothelial cell migration and in the formation of tight junctions.
Oxidized LDL (OxLDL) is implicated in endothelial dysfunction as well as the formation and progression of atherosclerosis.
This study was designed to investigate the effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase NG, NG-asymmetric dimethylarginine (ADMA) in patients and rats with diabetes, and to determine whether elevated endogenous ADMA is implicated in endothelial dysfunction or macroangiopathy in diabetes.
Peroxynitrite is a powerful oxidizing agent that is more cytotoxic than NO and is implicated in endothelial dysfunction [7].
GPR126 was initially isolated from HUVEC cultures that had been challenged with lipopolysaccharides or thrombin [14] and was implicated in endothelial cell function.
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