Sentence examples for been implicated in endocrine from inspiring English sources
The remainder of this review focuses on DUBs that have already been implicated in endocrine cancers.
PI3K/AKT/mTOR pathway activation has been implicated in endocrine resistance in breast cancer [ 9, 10, 12- 14].
These activated kinase pathways also modulate ER signaling [ 22] and have been implicated in endocrine resistance [ 23- 26].
Both of these epigenetic modifications can repress ER transcription and have been implicated in endocrine resistance [ 61].
Similarly, activation of downstream intracellular signaling via the ras-raf-mitogenic-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K /Akt pathway has been implicated in endocrine resistance [ 3- 5].
Numerous inhibitors of various pathways that have been implicated in endocrine resistance are in development, and it would be challenging to test all of the various combinations with different endocrine therapies in clinical trials.
GPCRs are a superfamily of membrane bound proteins characterized by seven transmembrane (TM) helices and many have been implicated in ADRs, endocrine disruption, and reproductive toxicity.
Smoking during pregnancy has also been implicated in neurological endocrine as well as maturational modifications observed in infants born to smoking mothers (4).
Although PI3K has been implicated in resistance to endocrine therapy of ER-positive tumors, several questions remain unanswered.
Penta has been implicated in hepatic and endocrine-related effects after repeated exposure but has relatively low acute toxicity.
