Retinoic acid has been implicated in embryonic endodermal patterning, especially during early pancreas formation [23], [24].
Wnt family proteins, cysteine-rich, and secreted glycoproteins, have also been implicated in embryonic development [10], [11], and cardiomyogenesis [12], [13].
By eliciting such dual effects, LSD1 has been implicated in embryonic development, cell differentiation and proliferation, stem and cancer cell biology.
The RA signaling has been implicated in embryonic axis formation as well.
Granulin-epithelin precursor (GEP) is an autocrine growth factor that has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation.
For instance, cell surface glycoproteins are important in cellular recognition and have been implicated in embryonic development, lymphocyte trafficking, and cancer metastasis, and there is resurging interest in glycoconjugates as therapeutics.
Mechanical forces, fibroblast growth factor (FGF -4 and transFGF -4g growth fandor (transformingimplicated in embryonic tendon development, yet the isolated effects of these factors on differentiatingrowth are unknown.
Epithelial-to-mesenchymal transition (EMT) is implicated in embryonic development and various pathological events.
Moreover, within this latter region, a conserved module was detected to which a complex of transcription factors, known to be implicated in embryonic pancreas formation, bind.
The encoded protein SFMBT2 (Scm-like with four mbt domains 2) belongs to the polycomb protein family which is implicated in embryonic development [ 33].
