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This is not unexpected, since both Uch37 and Rpn13 have been implicated in distinct molecular pathways presumably independent of their mutual interaction.
Ozaenae isolates have also been implicated in distinct types of infections such as bacteremia, urinary tract infections [68] or splenic abscess [69], and were variable for the presence of several virulence factors.
FGFR2 possesses the largest genomic structure among the FGFR family, with at least 22 exons and 21 introns and has been implicated in distinct types of cancer [ 47].
However, these proteases are often upregulated in various human cancers and have been implicated in distinct tumorigenic processes, such as angiogenesis and cell growth, death, and metastasis [ 141– 141].
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Arc is able to interact with multiple protein partners and is implicated in distinct neuronal mechanisms and forms of synaptic plasticity.
Nevertheless, IL-6 was implicated in distinct and diverse effects for the different co-cultures, suggesting that the underlying state of the EC may have been altered under the different culture conditions.
AUF1 has also been implicated in several distinct post-transcriptional processes.
The Na+, K+ ATPase has been implicated in two distinct neurological disorders: RDP and FHM (Cannon 2004; de Carvalho Aguiar et al. 2004; Haan et al. 2005; Pietrobon 2007).
Indeed, many ER chaperones have been implicated in substrate recognition for distinct classes of misfolded proteins, and several retrotranslocation routes have been proposed to mediate the transfer of different substrates across the ER membrane [17], [18], [19].
Mutations affecting the Na+, K+ ATPase alpha subunit have been implicated in at least two distinct human diseases, rapid-onset dystonia Parkinsonism (RDP), and familial hemiplegic migraine (FHM).
Epigenetic state has also been implicated in infertility by a distinct form of data, excess occurrence of model imprinting disorders among children conceived by ART (van Montfoort et al. 2012).
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