Sentence examples for been implicated in directed from inspiring English sources

Interestingly, Scrib has also been implicated in directed migration in other cellular contexts.

The APC tumor suppressor is mutated or downregulated in many tumor types, and is prominently localized to punctate clusters at protrusion tips in migratory cells, such as in astrocytes where it has been implicated in directed cell motility.

Three catalogs of human gene annotation were used to analyze EIAV integration site distributions, since LEDGF/p75 had previously been implicated in directing HIV integration to transcription units.

The superior parietal lobe has been implicated in directing visual attention to locations [33], and activation in this region often co-occurs with activation in the dorsolateral frontal regions (i.e., FEF) [34].

As such, TRAF6 has been implicated in directing the signals from representative members of a diverse array of receptor families, including the TNF receptor superfamily (TNFRSF), IL-1R/Toll-like receptor superfamily (IL-1R/TLRSF), TGFβR, IL-17R and IL-25R, and the NOD-like pattern recognition receptors [7], [8], [9], [10], [11], [12], [13].

To date, several intermediary 'nutrient sensing' molecules, such as those characterised in Saccharomyces cerevisiae and bacteria, have been implicated in directing amino acid signalling to mTOR [ 23, 24].

Recently, localized plumes of Ca2+ have been implicated in directing the highly localized deposition of individual papillae wall ingrowths in epidermal TCs of V. faba cotyledons [ 32].

In addition to its Myb domain, TRF2 possesses an N-terminal domain rich in basic residues that has been implicated in directing the binding of TRF2 to ss dsDNA junctions and unusual DNA structures.

NuRD-mediated deacetylation can direct the activity of the polycomb repressive complex 2 (PRC2) to silence gene expression (Reynolds et al., 2011), and NuRD has also been implicated in directing DNA methylation to a target gene in leukaemia cells (Morey et al., 2008).

The Hedgehog (Hh) pathway has been implicated in directing various aspects of the developing GI tract, notably the mucosa and smooth muscle growth, and enteric neuron patterning, while the Ret signaling pathway is selectively required for enteric neuron migration, proliferation, and differentiation.

Interestingly, we found that MMP8 may affect the metastatic behaviour of breast cancer cells and may be implicated in directing organ-specific metastasis.