Sentence examples for been implicated in direct from inspiring English sources
Since Snf1 is not required for ADR1 expression [5] but is required for DNA-binding by Adr1, one hypothesis is that Snf1 indirectly regulates Adr1 post-translationally. Protein kinase A (PKA) has been implicated in direct phosphorylation of Adr1.
TIMPs have conserved cysteine residues forming disulfide bridges [9] [11] and besides inhibiting MMPs, mammalian TIMPs have also been implicated in direct regulation of cell growth and apoptosis by interacting with the cell surface receptors integrin α3β1 and CD63 [11].
Acetate has also been implicated in direct myocardial toxicity.
Strikingly, the exposed face of H1 contains residues Trp57 and Leu58 that have been implicated in direct binding to CD4 (Grzesiek et al., 1996a; Figure 7D).
NANOG, OCT4 and SOX2 bind the intron 1 region of Xist and binding of these factors has been implicated in direct repression of Xist (Navarro et al. 2008).
In addition to transmission to domestic poultry, HPAI (H5N1)–infected mute swans have been implicated in direct transmission to humans in Azerbaijan (6 ).
Three catalogs of human gene annotation were used to analyze EIAV integration site distributions, since LEDGF/p75 had previously been implicated in directing HIV integration to transcription units.
The superior parietal lobe has been implicated in directing visual attention to locations [33], and activation in this region often co-occurs with activation in the dorsolateral frontal regions (i.e., FEF) [34].
As such, TRAF6 has been implicated in directing the signals from representative members of a diverse array of receptor families, including the TNF receptor superfamily (TNFRSF), IL-1R/Toll-like receptor superfamily (IL-1R/TLRSF), TGFβR, IL-17R and IL-25R, and the NOD-like pattern recognition receptors [7], [8], [9], [10], [11], [12], [13].
To date, several intermediary 'nutrient sensing' molecules, such as those characterised in Saccharomyces cerevisiae and bacteria, have been implicated in directing amino acid signalling to mTOR [ 23, 24].
