Among the c-Myc/miRNA targets we found that a subset has been implicated in differentiation.
Autophagy has been implicated in differentiation, morphogenesis and other developmental events in both invertebrates and vertebrates (Meléndez and Neufeld, 2008).
Beyond their roles for cytoprotection against stress, parasite heat shock proteins (HSPs) have been implicated in differentiation, stage development, and virulence.
Altered HOX gene expression has been implicated in differentiation, invasion, epithelialmesenchymal transition, apoptosis, and receptor signaling in a variety of cancer types [ 2- 8].
Although Egr1 has been implicated in differentiation of several cell types (18- 20) its role in adipogenesis has not been investigated.
In addition to these transcription factors, murine studies have identified several signaling pathways, including Wnt [ 6], Notch [ 7, 8] and MAPK [ 9] pathways, which have been implicated in differentiation of MUC5AC-producing cells.
We identify several processes and pathways differentially regulated in Ring1b-deficient ES cells, which are implicated in differentiation and embryogenesis.
It is implicated in differentiation, proliferation, cell-adhesion, and migration.
It was implicated in differentiation of neuronal cell lineages in the brain by the observation that overexpression of atoh8 in the developing retina induced neurogenesis while inhibiting gliogenesis [9].
The negatively regulated genes included FAS, TNFR, COL6A1, JAM2, FOXQ1, FOXO1, NESTIN, SMAD3, SLIT3, DKK1, WNT5A, BMP1, and GLIS3 which were implicated in differentiation processes as well as a number of novel genes (Table S1).
The negatively regulated genes included FAS, TNFR, COL6A1, JAM2, FOXQ1, FOXO1, NESTIN, SMAD3, SLIT3, DKK1, WNT5A, BMP1, and GLIS3 which are implicated in differentiation processes as well as a number of novel genes.
