Numerous cues have been implicated in different instances.
It has been shown that SOX2, MYC and OLIG2 are required to maintain proliferation in progenitor cells and they have been implicated in different types of cancer28,51,52,53,60.
Wnt signalling pathway has been implicated in different stages of mammary gland development as well as mammary oncogenesis [29,30,31], and it controls the expansion of the MaSC/early progenitor pool.
miR-21, a mature miRNA, has been implicated in different cell processes such as cell proliferation, mitochondrial damage, cell growth, chemosensitivity, cell cycle, genome instability, response to stress, mRNA cleavage, cell invasion and translation.
Four genes have been implicated in different clinical forms: MTM1 in severe X-linked cases, DNM2 in autosomal dominant adult-onset cases, BIN1 in autosomal recessive childhood-onset cases, and RYR1 in a few cases.
WRKY transcription factors have been implicated in different biological processes such as response to wounding, senescence, development, dormancy, cold and drought tolerance, metabolism and hormone signaling pathways.
It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies.
MAP4K3 has being implicated in different cellular processes based in biochemical and cellular assays carried out in different experimental systems.
The genes that were differentially regulated were implicated in different important processes such as cell adherence, growth and invasion.
They are implicated in different processes such as epithelial-mesenchymal interactions, skeletogenesis and carcinogenesis [1], [2], [3].
These molecules play important roles in the induction of plant defence responses upon pathogen attack and are implicated in different forms of resistance [14], [15].
