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Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices.
Galvanotaxis, the migratory response of cells in response to electrical stimulation, has been implicated in development and wound healing.
D6 proteins have been implicated in development and cellular differentiation.
POU domain proteins have been implicated in development, replication, growth and cell cycle arrest, and differentiation [4] [6].
Increased expression of FAT/CD36, FATP1, UCP2 and UCP3 have all been implicated in development of lipotoxic heart disease [20], [52], [53].
Importantly, high level of Mcl-1 has been implicated in development and maintenance of both solid tumors and haematological malignancies and contributes to drug resistance [14].
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The sirtuin (SIRT /nicotinamide adenine dinucleotide (NAD) system is implicated in development of type 2 diabetes (T2D) and diet-induced obesity, a major risk factor for T2D.
Autonomic dysfunction, in particular under-regulation of heart rate (HR) by the baroreflex, is implicated in development of insulin resistance (IR).
CD36 facilitates oxidized low density lipoprotein uptake and is implicated in development of atherosclerotic lesions.
Ubiquitously expressed calpain-I (μ-calpain) and calpain-II (m-calpain) proteases are implicated in development of apoptosis.
Evidences are suggesting that DNA damage is implicated in development of systemic lupus erythematosus (SLE).
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