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Initially, Smurfs have been implicated in determining the competence of cells to respond to TGF-β/BMP signaling pathway.
Cyclic diguanylate (c-di-GMP) [bis(3′,5′ -cyclic diguanylic acid] is a prokaryotic cyclic dinucleotide second messenger that has been implicated in determining the timing and amplitude of complex biological processes from biofilm formation and virulence to photosynthesis.
Previously, the relative densities of IKr and IKs have been implicated in determining restitution slope [30], [31].
Currently about 50 genes have been implicated in determining RLS.
Defects of PTMs have also been implicated in determining cell fate and oncogenesis [ 3, 4].
Residue 114 has been implicated in determining tapasin, and therefore TAP association [ 24].
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However, Hoxb5 is implicated in determining limb positions along the anteroposterior axis [ 21].
These findings may suggest that several genes in the hormone metabolism/growth factor pathways are implicated in determining MD.
These findings may suggest that several genes in the hormone metabolism and growth factor pathways are implicated in determining MD.
Finally, non-coding mRNAs as well as conserved non-genic sequences, which have been described within Hsa21, might be implicated in determining the DS phenotype [ 57].
Since UCHL1 is implicated in determining the levels of free ubiquitin, and is important for maintaining protein homeostasis in the cell, we investigated ER stress in CSMN of UCHL1−/− mice.
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