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Seagrass leaves are often densely covered by epiphytic algae which can suppress seagrass productivity and has been implicated in declines of seagrass meadows worldwide.
Furthermore, parasites have been implicated in declines of natural and commercial pollinators, such as bumblebees, worldwide [ 25, 46, 47], and thus knowledge of genes and pathways involved in immunity and parasite defence is highly important.
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Bacteria have also been implicated in declining coral health.
While tamoxifen has been implicated in decline in cognitive function (Paganini-Hill and Clark, 2000), these data do not come from double-blind randomised placebo-controlled trials, and so the issue remains controversial.
Advancing age is associated with reductions in nitric oxide bioavailability and changes in metabolic activity, which are implicated in declines in motor and cognitive function.
Reduced availability of NO, important for angiogenesis and maintenance of endothelial integrity, together with increased generation of O2−*, a marker of inflammation and mediator of atherosclerosis, are implicated in decline of vascular function in diabetes [4] [7].
In a study of older rats, van Praag et al. 2005 [ 75] found that those that exercised on a running wheel showed a reversal in declines of neurogenesis (decline in neurogenesis has been implicated in cognitive decline).
Previous investigations of timber management effects on capercaillie have shown contradictory results within Europe; habitat loss and fragmentation due to intensive forest management have been implicated in population declines, while other studies have suggested neutral or positive effects.
El Niño-related droughts have also been implicated in periodic declines in Indian agricultural output.
More broadly, the spillover of pathogens from commercial to wild bumble bees is an example of human-mediated pathogen invasion, which has been implicated in wildlife declines and extinction events over the past 40,000 years [6], [56], [57].
High soil aluminum and low soil calcium concentrations resulting from acid deposition have been implicated in this decline.
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