Sentence examples for been implicated in critical from inspiring English sources

Vitamin A-mediated signaling pathways have been implicated in critical processes involved in the formation of the bladder from the urogenital sinus as well as the maintenance of a differentiated urothelial phenotype.

Ischemia and mitochondrial dysfunction have been implicated in critical illness.

Epigenetic changes through altered DNA methylation have been implicated in critical aspects of tumor progression, and have been extensively studied in a variety of cancer types.

We believe this to be unlikely since stk33 has been implicated in critical functions such as spermatogenesis and organogenesis [ 9] and there is no obvious indication to assume that neognath birds can manage without these functions of stk33 whereas paleognath birds and other vertebrates cannot.

They have now been implicated in critical protective functions in auto-immune disease (Sakaguchi, 2005), transplantation tolerance (Waldmann et al., 2004), gastro-intestinal homeostasis (Coombes et al., 2005) and inflammatory disease (Wahl et al., 2004b), and conversely, are a pivotal component of the pathophysiological immune tolerance induced by tumours (Munn and Mellor, 2006).

The 80′s loop has been noted to exhibit a wider diversity of conformations than the rest of the protein between different structures of FKBP12 as well as among structures of the various FKBP modules of the larger members of this protein family for which this loop has also been implicated in critical protein recognition interactions [ 51].

Thus, collectively, review of the literature reveals that a number of the proteins encoded by the mRNAs we identified are implicated in critical functions of the podocyte and thus, by extension, may potentially be involved in glomerular pathogenesis as well.

The majority of these genes are implicated in critical cellular processes such as chromosome segregation, nutrient-sensing, stress response and mitochondrial function.

Etomidate is well tolerated and not inferior to ketamine but because it is implicated in critical illness-related corticosteroid insufficiency (CIRCI) [ 1], its utilization in septic shock patients is controversial.

MiRNAs are known to play multiple roles in carcinogenesis, immune responses and organ development [6], [7], and have been implicated in many critical cellular processes, including apoptosis, proliferation, and differentiation [8].

MiRNAs have been implicated in many critical biological processes.