Conspicuous amongst this treasure trove of interesting candidates were a surprising number of genes that have been implicated in controlling apoptosis, a process by which unwanted cells are safely destroyed in a controlled, predictable way.
However, heme and hemoproteins have been implicated in controlling the expressions of cell cycle regulators and cell growth in mammals.
Additionally, we use CRISPRs to generate cos2/kif7mw406, a mutation in the kinesin-4 family member cos2/kif7 that has been implicated in controlling ciliary architecture and Hedgehog signaling to test whether it may be functioning redundantly with osm-3/kif17.
Similarly, chemokines have been implicated in controlling HSC/HPC homing [1].
Both molecules have been implicated in controlling Treg cell migration [41], [43], [44].
Oxygen concentration has been implicated in controlling oligodendrocyte progenitor proliferation and survival [43].
The latter has also been implicated in controlling angiogenic sprouting [11].
Oncogenic RAS through RAF/MEK/ERK and PI3K-AKT have been implicated in controlling VEGF expression [27].
Since the Toll and Jak-Stat pathways have also been implicated in controlling viral infections in Drosophila, we finally investigated if these pathways affect the Nora virus.
As a positive regulator of Cdk 4 and Cdk 6, cyclin D1 has been implicated in controlling the G1 phase of the cell cycle as shown in human colon adenocarcinomas [34].
Cell migration is an actin-dependent process and many proteins that regulate F-actin polymerization, de-polymerization, branching, cross-linking or bundling have now been implicated in controlling migration [3].
