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Interestingly, both have been implicated in conferring resistance to apoptosis induced by anticancer drugs.
The epsilon class of insect GSTs has previously been implicated in conferring insecticide resistance in several insect species.
Enzymes from all three families have been implicated in conferring resistance to pyrethroids in other insect species (e.g. [ 11- 15]).
C35 has recently been implicated in conferring invasive potential in prostate cancer cell lines (Dasgupta et al, 2009).
Recently, insulin-like growth factor-1 (IGF-1) has been implicated in conferring protection to other forms of hyper-inflammatory conditions by stimulation of regulatory T cells.
Several mechanisms - such as drug efflux via breast cancer resistance proteins, more efficient DNA repair mechanisms, masking of receptors, and inactivation of PTEN - have been implicated in conferring this phenotype.
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miR-98 was implicated in conferring resistance to cisplatinum in head and neck squamous cell carcinoma [62].
HLA polymorphism is implicated in conferring genetic susceptibility to a large number of immune mediated diseases, including some cancers.
In lung cancer, fibronectin expression is increased and has been implicated in promoting lung cancer growth and conferring resistance to therapy [ 11, 12].
In fact, ankyrin repeats of HIP14 have been implicated in specificity determination since they can confer HIP14-like specificity to DHHC3 [28].
The activation of the Akt pathway has been implicated in protecting cells by many death stimuli, thereby conferring cell survival [10], [13].
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