Moreover, plasmalogens have been implicated in cholesterol transport.
Both CETP and LIPC have previously been implicated in cholesterol homeostasis in other genome-wide association studies [4], [9], [10], [12], [16].
Calmin has not previously been implicated in cholesterol or lipoprotein metabolism nor has CLMN variation been associated with any metabolic traits.
LAMP-2 has been implicated in cholesterol transport from the lysosome [ 18, 24].
The SORL1 protein belongs to a super family of low-density lipoprotein receptors that bind apolipoprotein E and have been implicated in cholesterol metabolism [ 42].
They have been shown to be implicated in cholesterol turnover, inflammation and in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.
Oxysterols have been shown to be implicated in cholesterol turnover, inflammation and in neurodegenerative diseases such as Alzheimer's disease (AD) [3], [4] and multiple sclerosis (MS) [5], [6].
Interestingly, decreased DHEA levels have been implicated in high cholesterol, inflammation, immune disorders, diabetes and osteoporosis [ 42, 43], and DHEA replacement has attracted considerable attention over recent years [ 44].
Low-density lipoprotein cholesterol, the major carrier of blood cholesterol, has been implicated in the buildup of cholesterol in atherosclerotic plaques.
EGR1, known to regulate many genes related to cell proliferation, apoptosis and immune response [ 37, 38], has also been implicated in regulation of cholesterol biosynthesis genes [ 39], supporting the interactions depicted in the network shown here.
If dietary changes and exercise do not successfully reverse or arrest lipid changes, the clinician may consider altering the ART regimen; however, both PI and NNRTI-based therapies have been implicated in ART-related cholesterol elevations [ 4].
