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These findings were significant for a better understanding of tumor formation caused by inactivation of Tsg101 (tumor susceptibility gene 101), the human vps23 homolog, which has been implicated in cervical, breast, prostate and gastrointestinal cancers [27] [31].
Deletions of several genetic loci have previously been implicated in cervical dysplasia and cancer.
Furthermore, altered expression of MIR199A has been implicated in cervical carcinoma and suggests a role in tumorigenesis [ 48].
MiR-143 and miR-145 have previously been shown to suppress cell growth in CSCC and they have consequently been implicated in cervical carcinogenesis (Wang et al, 2008).
This epithelial-mesenchymal transition process has been implicated in cervical carcinogenesis, which could explain CIN predominance in the posterior cervix [ 30, 31].
Given that PAHs from smoking have been implicated in cervical cancer, the carcinogenic potential on the cervical and vaginal mucosal has been also explored for solid fuel use in human and animal models [ 11- 13].
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Herpes, gonorrhoea, chlamydia, and, yes, the human papillomavirus – which is implicated in cervical cancer and can cause genital warts – can be transmitted through oral sex.
Human Papillomaviruses (HPV) are implicated in cervical cancer and other ano-genital tumors.
Together, our findings from both in vitro and in vivo studies suggested that RRM2 might be implicated in cervical cancer development at least partly through enhancement of angiogenesis.
These observations hint the possibility that as the specific ligand to Flt-4, VEGF-C may be implicated in cervical cancer progression by direct impacts on tumor cells.
Moreover, certain persistent viral infections have been implicated in tumorigenesis, like cervical carcinoma caused by human papillomavirus or nasopharyngeal carcinoma (NPC) and Burkitt's lymphoma by Epstein-Barr virus (EBV).
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