The Warburg effect has been implicated in cell transformation, immortalization, and proliferation during tumorigenesis [10].
Although PTEN has been implicated in cell adhesion and migration, the underlying molecular mechanism is unknown.
These ubiquitous receptors have been implicated in cell development, cell proliferation, and even cancer.
ZAK has been implicated in cell cycle arrest regulation through its function on decreasing cyclin E expression.
The 22 members of the fibroblast growth factor (FGF) family have been implicated in cell proliferation, differentiation, survival, and migration.
Cyclooxygenase-2 (COX-2 -controlled COX-2 -controlledstaglandin E2 (PGE2) has been impliCOX-2 -controlledwth and metastasis in many cancers.
Electrostatic interactions have also been implicated in cell interactions with metals.[37, 38] At circum-neutral pH these are dominated by COO- groups (pKa ≈ 5) possibly associated with the LPS, but also with proteins.
DJ1 has also been implicated in cell protection against stresses including chemotherapy and oxidative stresses, [42].
Cell survival mediated by integrin engagement has been implicated in cell adhesion-mediated drug resistance.
Constitutive activation of the CD40 pathway has been implicated in cell transformation and neoplastic growth [26].
Within the PM, chol has also been implicated in cell signaling processes [3].
