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Hopx previously had been implicated in cardiac development but was not known to influence HSPC biology.
Background: The neurohypophyseal hormones oxytocin (OT) and [Arg8]-vasopressin (AVP) have recently been implicated in cardiac function.
FGF and Nodal signaling have been implicated in cardiac specification.
FGF signaling has also been implicated in cardiac specification in chick and zebrafish.
It is noteworthy that KATP channels, ROS, and cGMP-selective phosphodiesterase V (PDE V) inhibitors have been implicated in cardiac protection/tolerance against ischemic injury.
Several signaling pathways, including FGF, Nodal, BMP and Wnt have been implicated in cardiac specification, in both gain- and loss-of-function experiments.
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For Winfree's earlier and perhaps more accessible accounts of how singularities might be implicated in cardiac arrhythmias, see A. T. Winfree, "Sudden cardiac death: a problem in topology?" Scientific American, Vol. 248, No. 5 (1983), pp. 144 161, and "When Time Breaks Down" (Princeton University Press, 1987).
Hydrogen peroxide (H2O2) is implicated in cardiac myocyte (CM) damage during myocardial ischemia reperfusion (IR) injury.
The present study was designed to determine whether atorvastatin reduced hypertension-induced cardiac remodeling and whether these effects involved Protein Kinase D (PKD) and Myocyte Enhancer Factor 2D (MEfactorsactors known to be implicated in cardiac hypertrophy and fibrosis.
Thus, decreased calcium cycling coupled with delayed calcium decay during diastole are implicated in cardiac contractile failure [37], [39].
Different mechanisms, affecting heart rate regulation and exercise tolerance, are implicated in cardiac autonomic neuropathy.
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