EBV has been implicated in carcinogenesis since the discovery of its implication in Burkitt's lymphoma in sub-Saharan Africa in the 1960s [ 9].
The acyl-CoA synthetase 4 (ACSL4) has been implicated in carcinogenesis and neuronal development.
Chronic inflammation has been implicated in carcinogenesis, with increasing evidence of its role in lung cancer.
Individual components of the innate and adaptive immune response have also been implicated in carcinogenesis.
The HBV regulatory protein X (HBx), which is degenerate in avian HBVs, has been implicated in carcinogenesis.
Insulin resistance (IR) has been implicated in carcinogenesis, but there is no consensus regarding its involvement in ovarian cancer.
Notch receptors and ligands are expressed in breast cancer cells as well as in the stromal compartment and have been implicated in carcinogenesis.
GPR17 and GRIN1 have not been implicated in carcinogenesis to date.
Inhibition of Caspase-9 with a dominant negative construct (Casp9DN) blocks apoptosome function, promotes viability and has been implicated in carcinogenesis.
In addition, we have now identified specific genes (e.g, INHBA and WIF1), which while previously implicated in other cancer types, to our knowledge have not previously been implicated in carcinogenesis of OSCC.
Failure to complete cytokinesis has been implicated in carcinogenesis [14], [19], [20], and our data demonstrate that the Beclin 1 - FYVE-CENT complex may play important roles in controlling this process.
