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Signaling by the epidermal growth factor receptor (EGFR) plays a role in cell survival and has been implicated in bone development and homeostasis.
During the past years, several signaling molecules have been implicated in bone development and osteogenesis [8].
Indeed blood vessel development has previous been implicated in bone generation [ 24, 25].
However, depending on their concentrations levels, they have also been implicated in bone resorption [ 51 ].
Syndecan 3 (SDC3) has also previously been implicated in bone signaling [ 43].
OPN has been implicated in bone invasion in a number of cancer types and other intracranial tumors [ 45].
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In humans, its physiological role is implicated in bone resorption, antigen processing and protein turnover [ 1].
31 This gene encodes a high-mobility group chromatin-associated protein and increased expression is implicated in bone metastasis.
In particular, BMP5 is implicated in bone morphogenesis and in the formation of the skeletal pattern, in addition to having roles in other organs [ 15].
Novel pathways were identified in this study including Periostin (POSTN) and Leptin (LEP), which are implicated in bone remodeling by osteoblasts.
Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other diseases including cancer.
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been described in bone
been implicated in plaque
been uncovered in bone
been investigated in bone
been implicated in neuroinflammation
been demonstrated in bone
been implicated in plant
been made in bone
been implicated in insulin
been tested in bone
been reported in bone
been implicated in cancer
been implicated in cholesterol
been implicated in atherosclerosis
been proposed in bone
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