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Regulation of the Nrf2– ARE signaling has also been implicated in basic health, lifespan, and aging.
Members of this enzyme family have been implicated in basic cellular processes as well as virulence (reviewed in [ 10]).
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The MMPs are implicated in basic processes of tumour progression, such as degradation of basement membrane and extracellular matrix, stimulation of cellular proliferation, cellular motility, resistance to apoptosis and angiogenesis.
Although heparin has not been implicated in binding to Slit2 D4, the large basic regions and the conspicuous sulphate-binding site suggest a possible interaction.
Such an unstructured region with multiple highly basic residues, which has been implicated in binding to other factors [50], would be particularly susceptible to charging.
CA IX is an exceptional member of this family because in addition to the basic CA function, it has been implicated in several other physiological and pathological processes.
Indeed, in addition to aromatic side chains (Tyr10), several aliphatic (Ref. 81) and basic residues such as His13 have been implicated in GM1 Aβ interactions (Ref. 83).
Other growth factors such as CTGF, basic (b FGF, and angiotensin II have been implicated in wound healing and fibrosis in a variety of tissues [ 56- 59].
This neuronally expressed basic helix-loop-helix transcription factor has been implicated in schizophrenia [ 76, 77]and bipolar disorder [ 77], and is frequently deleted or inactivated in many cancers.
Twist, a basic helix – loop – helix transcription factor, has been implicated in cell lineage differentiation and the inhibition of oncogene-dependentand p53-dependent cell death.
The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated in neuronal development in the hypothalamus.
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