While the BS1 region of GcvB has not been implicated in base-pairing with other targets before, the BS2 site partially overlaps with the GcvB target region for the phoP mRNA in E. coli (Coornaert et al, 2013).
These cells have been implicated in amyloidogenesis based on their close ultrastructural relationship with amyloid deposits [31], [32], phagocytic function [33], and their proteolytic enzymes [34].
Sro7p and Sro77p have been implicated in secretion based on genetic studies demonstrating decreased secretion of invertase and an accumulation of secretory vesicles in the absence of SRO7 and SRO77 [19].
The phosphatidylinositol 3-kinase (PI3K) pathway has long been implicated in aging based on the demonstration that attenuating insulin/IGF1/FOXO activity extends lifespan in C. elegans [ 27].
The NOTCH4 (neurogenic locus notch homolog protein 4) gene, located at the centromeric end of the HLA class III region, has been implicated in SCZ based on evidence from several genetic studies [ 6].
Specific trans-acting factors that have been implicated in (CTG n CAG n instability based on crosses between transgenic TNR mice and mice defective in DNA mismatch repair or base excision repair [ 20, 71, 72, 102, 130, 131].
Both PKC α and PKC ɛ have been implicated in cardiac hypertrophy, based on in vivo and in vitro studies, although they probably have different roles.
Estrogen has been implicated in autoimmune diseases based on its ability to promote B-lymphocyte survival and activation, thus facilitating autoreactivity [ 53].
Aberrant activation of EMT has been implicated in this process, based on studies with a mouse model and human cancer cell lines.
Notably, Sema3C has never been found to bind plexins directly; however, both PlexinA2 and PlexinD1 have been implicated in Sema3C signalling, based on genetic evidence in developmental models (Epstein et al, 2015).
