The porphyrin binding property of GUN4 has been implicated in ROS attenuation but conclusive experimental support is lacking.
Ankyrin repeat proteins are thought to be involved in poxvirus host-range [ 15], and have previously been implicated in the attenuation of sheeppox virus [ 16].
Collagen has been implicated in the attenuation of loads at higher loading rates [ 25] while collagen damage leads directly to increases in phase angle [ 26].
Most of the genes deleted in PEPV and FeP2 are members of multi-gene families, the disruption of which has been implicated in the attenuation of poxviruses [ 10], however there are several other deletions of significant ORFs.
SIRT6 has been implicated in DNA repair, telomere maintenance, attenuation of inflammation, glucose homeostasis, and inhibition of obesity-induced metabolic dysfunction.
The accumulation of ROS and evidence of oxidised proteins has been implicated in sarcopenic muscle, however the attenuation and suppression of this disease remains contradictory.
The IGF-IR activation and overexpression have been implicated in many cellular processes, including cell migration, proliferation, and attenuation of cell survival and are related to the malignant phenotype [ 31, 36, 37].
Increased mTOR activation has been implicated in a wide variety of different cancers, and AMPK-mediated attenuation of anabolic metabolism and/or mTOR signaling by metformin may contribute to the antitumor effects of metformin in some situations.
PA and NP proteins have also been implicated in host range restriction; for example, an avian virus NP segment against a background of a human virus resulted in attenuation in squirrel monkeys (33 ).
