Sentence examples for been implicated in attenuating from inspiring English sources
Likewise, the decreased expression (4.28 fold) of thrombospondin 1 (THBS1), as observed in senior dogs fed APB, may also indicate the predisposition of the liver to inflammation and fibrosis with age because THBS1, a mediator of TGF-β signaling pathway, has been implicated in attenuating inflammatory response and fibrosis by limiting angiogenesis in the heart [40].
The capacity of garlic to modulate diabetes-induced up-regulation of selective RAGE polymorphic variants may be implicated in attenuating the detrimental consequences of excessive RAGE signaling manifested by diabetes-associated disorders.
Thus, D-4F administration is implicated in attenuating UFP-mediated increases in oxidative products of fatty acids in the intestines.
Further, SIRT4 has been implicated in regulating lipid metabolism by attenuating peroxisome proliferator-activated receptor α (PPARα) and thus repress rates of fatty acid oxidation in the hepatocytes (Laurent et al., 2013).
Moreover, RASSF1C has also been implicated in promoting cell migration and attenuating apoptosis in breast cancer cells [ 37].
Wnt signaling has been implicated in both promoting osteoblast [45] and attenuating osteoclast function [23].
These non-photic pathways have been implicated in generating mid-day phase advances and attenuating glutamatergic, light-stimulated phase shifts during the nighttime [46], [47], [48], [49].
The phosphatidylinositol 3-kinase (PI3K) pathway has long been implicated in aging based on the demonstration that attenuating insulin/IGF1/FOXO activity extends lifespan in C. elegans [ 27].
Finally, ER stress has also been implicated in the pathophysiology of pancreatitis; the UPR attenuates alcohol-induced pancreatic damage [ 56], whereas PERK-deficiency impacts on the viability of the exocrine pancreas [ 71].
Caloric restriction attenuates processes that have been implicated in cellular senescence, including generation of reactive oxygen species (ROS), growth hormone/insulin-like growth factor-1 signaling, and inflammation [ 10- 12].
The minimally attenuated residues include those that have previously been implicated in forming phase changes of the FG repeat regions (Ader et al., 2010).
