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Platelet leukocyte aggregates have been implicated in atherogenesis.
CSE and endogenous H2S have also been implicated in atherogenesis: Overexpression of CSE exerted anti-atherosclerotic effects [45], whereas CSE knockout promoted disease progression in a murine model of diet-induced atherosclerosis [46].
It seems likely therefore, that the IL-1 mediated increase in ROS and decreased NO production are the central mechanism of atheroma development as both of these have individually been implicated in atherogenesis.
Both have been implicated in atherogenesis (10).
PPARγ has long been implicated in atherogenesis (Diep and Schiffrin, 2001; Li and Glass, 2002).
Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthesis inhibitor, and insulin resistance (IR) have been implicated in atherogenesis.
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When ligated, RAGE is implicated in atherogenesis and chronic inflammatory diseases by amplifying inflammatory events in tissues previously sensitized by lipid deposition or inflammatory triggers [ 12].
Among the proteins that are implicated in atherogenesis and vascular diseases, CHI3L1 was the only one that is predicted as linked to all pathways.
The impact of advanced glycation end products has been implicated in diabetic atherogenesis (4).
Besides, the formation of advanced glycation end products (AGEs) has been implicated in coronary atherogenesis [ 15– 17].
In addition, omega-6 fatty acids are consumed at a higher level compared with omega-3 fatty acids in a standard western diet and they have been implicated in coronary atherogenesis [ 21].
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been implicated in fibrosis
been implicated in activation
been implicated in maintenance
been implicated in depression
been implicated in carcinogenesis
been implicated in control
been implicated in lifespan
been implicated in colon
been implicated in progression
been implicated in response
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been implicated in microtubule
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