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Hsp70 chaperones have been implicated in assisting protein folding of newly synthesized polypeptide chains, refolding of misfolded proteins, and protein trafficking.
The pleckstrin homology motif has been implicated in assisting the interactions between FACT and RPA, an essential protein involved in DNA replication and repair (VanDemark et al. 2006).
CCL2 is a chemokine that has been implicated in assisting cancer metastasis by mediating a crosstalk between cancer cells and the stromal cells that are present in the tumor microenvironment [ 90].
Given that both Rrm3 and Pif1 have been implicated in assisting lagging strand synthesis, a logical expectation is that a Rad53-mediated inhibition of Rrm3 and Pif1 helicase activities would preferentially affect the polymerization of the lagging strand.
In an invasive breast cancer mouse model, macrophages have been implicated in assisting tumor cell motility by participating in an epidermal growth factor- (EGF-) CSF-1 paracrine loop where tumor cells secrete CSF-1 and macrophages contain the corresponding receptor and vice versa [ 66, 67, 69, 75].
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Facebook has been pushing its privacy friendly message in earnest since it was implicated in assisting NSA surveillance programmes, which it denied knowledge of.
LPA has been implicated in the development of the cardiovascular system, assisting in its progression to a fully functional state [ 3, 4].
Importantly, ceruloplasmin has been implicated in iron metabolism due to its ferroxidase activity, assisting ferroportin on cellular iron efflux.
However, for protic residues that interact directly with the phenol hydroxy group in PHHY, and have thus been implicated in mechanism,[ 12] Asp54, which is thought to assist in phenolate stabilisation, is replaced in HbpA by His48, and Tyr289, which is thought to act as the proton donor to the FAD peroxo-anion is replaced by Ala240.
Several ubiquitin genes have been implicated in ASD [ 86], including PARK2 that encodes parkin, which assists in mitochondria dystruction [ 87].
FMRP has been implicated in transporting mRNAs to dendrites [ 14- 16] and can be regarded as a potential candidate to assist in pre-miR transport as well.
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