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Indeed modulation of the expression of all of these transcription factors - E12 [ 35]; FREAC2 [ 36, 37]; FOXO4 [ 38]; LEF1 [ 39]; NFAT [ 40]; GATA4 [ 41]; ETS2 [ 42] have been implicated in altered gene expression during EMT.
Several proinflammatory cytokines and chemokines have been implicated in altered nociceptive processing.
The physiological withdrawal of ovarian sex steroids, estrogen, and progesterone has been implicated in altered metabolism after menopause.
Additionally, JNK activation has been implicated in altered neurofilament phosphorylation in the PNS of diabetic rats [ 46].
Loss of phospho-serine-dependent 14-3-3 14-3-3 14-3-3een implicated in altered LRRK2 interaction with ARHGEF7 [ 67] and a lack of release in exosomes [ 66].
Changes in cell-cycle length have previously been implicated in altered cell-cycle progression (Dehay and Kennedy, 2007; Kim et al., 2009; Qu et al., 2013).
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The PI3K/AKT signaling pathway has also been implicated in altering breast cancer response to multiple therapies [1], [10], [11], [14].
More recently, Myc deregulation has been implicated in altering cellular metabolism, particularly by inducing both the Warburg effect and a reliance on exogenous glutamine [18], [25], [49].
The electrostatic properties of helix macrodipoles have previously been implicated in altering the reactivity (significantly reducing the pKa) of cysteine residues positioned at the N-termini of α-helices [30].
Whereas the low levels of hypophosphorylated RB1 reported for other Lmna/LMNA deficient cells have been implicated in altering the G1/S transition, our findings with LmnaDhe/+ fibroblasts suggest that the influence of RB1 extends to mitosis as well [11], [19], [26], [28], [39] [42].
CIA1 is a yeast gene that has not been implicated in altering yeast prion propagation.
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