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Excitatory amino acids as glutamate have been implicated in alcohol hangover and may be responsible for the seizures and anxiety observed during withdrawal.
References to studies in which the same gene or orthologous gene have been implicated in alcohol sensitivity are given in square brackets.
Rs1659400 is in strong LD with several other SNPs within the NTRK1 gene, some of which have been implicated in alcohol dependence and depression [ 42, 43].
ct, an early developmental homeobox transcription factor with pleiotropic effects on multiple phenotypes, has been implicated in alcohol sensitivity in Drosophila [ 44], as have its orthologs in mice [ 45, 46] and humans [ 14, 47].
Working memory deficits have been implicated in alcohol and substance use disorders (Ambrose et al., 2001; Bechara and Martin, 2004) as well as in PG (Leiserson and Pihl, 2007) and may bear upon response perseveration previously observed in these groups.
In addition, stress response systems in the brain have been implicated in alcohol initiation and in the escalation of alcohol use from episodic use to abuse and, ultimately, dependence.
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Large-scale gene profiling of the liver reveals changes in the expression of a number of genes that have never been implicated in alcohol-induced injury.
Given their role in facilitating inflammation, it is not surprising that alcohol-activated microglia have been implicated in alcohol-induced inflammatory pathways.
These genes participate in known genetic and physical interaction networks; are in evolutionrily conserved signalling pathways, including catecholamine neurotransmitter biosynthesis and early development of the nervous system; and have been implicated in alcohol-related phenotypes in mice and humans.
GABA receptor systems have long been implicated in alcoholism, and GABAergic drugs have demonstrated efficacy in altering alcohol intake in some rodent models.
In addition to being implicated in alcohol-induced neurotoxicity, microglia also might contribute to the processes that lead to the development of alcohol use disorder.
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been implicated in regulation
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