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Although the hippocampus has often been implicated in aggressive behavior, we did not find an association between aggression and hippocampal volume.
These regions have also been implicated in aggressive behavior in rodents [21].
Thrsp (thyroid hormone responsive SPOT14 homolog) is expressed in hippocampus, but the human protein homolog, S14, has also been implicated in aggressive breast cancer.
Furthermore, K- ras has been implicated in aggressive ICC downstream of the biliary tree with increased expression levels in metastatic lymph nodes [ 121]; therefore K- ras expression correlates to poor prognosis [ 122].
Deregulation of E2F activity and early cell cycle progression has also been implicated in aggressive prostate cancer (Sharma et al, 2010), but the precise role of E2Fs in cancer is dependent on a balanced interplay with other regulatory factors and these interactions in prostate cancer need to be elucidated.
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The bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) is implicated in aggressive prostate cancer.
Breast cancers may express a complex profile of related but distinct glycans sharing similar terminal immunodominant sugar GalNAc, which may be implicated in aggressive biological behaviour.
By Jon Michaud October 14, 2009 As reported in the Times and elsewhere, the journal Science this week published a study linking chronic fatigue syndrome to a possibly contagious retrovirus that has also been implicated in an aggressive form of prostate cancer.
Rac1 activity has also been implicated in the aggressive phenotype.
Chromosomal translocations that couple MLL1 to one of more than 60 known fusion partners have been implicated in driving aggressive adult and childhood leukaemias [ 73].
The methylation of H3K27 mediated by EZH2 has been implicated in the aggressive phenotype of cancer cells through the repression of a panel of tumor suppressor genes [ 24, 25].
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