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Mitochondria and respiration have been implicated in ageing.
In Caenorhabditis elegans [ 70] and a number of tissues, including heart [ 71] and brain [ 72], transcription factors have been implicated in ageing.
Also in yeast, autophagy has been implicated in ageing (reviewed in [ 33]).
miR-669c has recently been implicated in ageing [ 44] and correlates with the decline of liver regeneration.
Oxidative damage has been implicated in ageing and many human diseases and disorders including cancer, cardiovascular diseases especially atherosclerosis, diabetes and chronic inflammatory diseases [ 1].
Oxidative stress has been implicated in ageing and many age-associated diseases, such as cancer, diabetes, cardiovascular disease and neurodegenerative diseases.
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Reduced telomere length, or its accelerated attrition, has been implicated in aging, mortality, and several human diseases, including respiratory diseases.
Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer.
They have been implicated in aging processes and the seven human isoforms, Sirt1 7, are considered therapeutic targets, e.g., for cancer and neurodegenerative disorders.
The microRNA, miR164, has been implicated in aging in Arabidopsis and was part of a complex genetic chain that changed as leaves aged.
In this regard, one area of major interest concerns the effects of RESV on the activity of sirtuin 1 (SIRT1), an NAD+-dependent histone deacetylase that has been implicated in aging.
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