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Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking.
LGALS3 encoding galectin-3 has been implicated in advanced stage disease [ 30].
Leptin and insulin/IGF-1 are high in obese men (Hoda et al, 2010) and suppress androgen levels, moreover leptin has been implicated in advanced and high-grade prostate cancer in two case control studies (Saglam et al, 2003; Ribeiro et al, 2006).
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These compounds are inhibitors of aldose reductase, an enzyme that has been implicated in the formation of cataracts in advanced stages of diabetes mellitus.
These shed membrane vesicles have been implicated in the immunosuppressive events associated with advanced cancers.
Accumulation of advanced glycation endproduct (AGE) has been implicated in the pathogenesis of diabetic complications.
The impact of advanced glycation end products has been implicated in diabetic atherogenesis (4).
TNF- α has been implicated in insulin resistance and liver fibrosis as well as advanced stages of NAFLD in humans [ 28].
The receptor for advanced glycation end products, RAGE, has been implicated in pathogenesis of many diseases.
Activation of receptor for advanced glycation end products (RAGE) has been implicated in many chronic diseases, including diabetic complications.
The receptor for advanced glycation end-products (RAGE) has been implicated in smoke-induced inflammatory effects; however, its role in the oral cavity is unknown.
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