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The team focused on a handful of genes, all of which had been implicated in adaptation to low-oxygen environments.
Other insertions were found in genes that have been implicated in adaptation of H. influenzae to infection of the murine lung (HI0334, HI0910 and HI1605).
Previous transcriptomic analyses uncovered 210 regulatory sRNA candidates expressed in L. monocytogenes, some of which have been implicated in adaptation to iron limitation, oxidative stress, low temperature or intracellular survival [ 35- 41].
Duplication and diversification of tubulin genes has also been implicated in adaptation to extreme environments in the Antarctic fish Notothenia coriiceps[ 21], which expresses at least nine different alpha tubulin isotypes that vary in stability and polymerization rates at extremes of temperature [ 22].
Because of its frequent overexpression in transformed cells, stimulatory effect on cell growth [ 13], and ability to upregulate the transcription of several glycolytic enzymes [ 14] the "early response" gene, c-myc, has been implicated in adaptation of transformed cells to hypoxia [ 15].
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EPS has been implicated in cold adaptation in cryophilic and mesophilic bacteria in response to cold stress (Krembs and Deming, 2008).
Cysteine is a component in organic compounds including glutathione that have been implicated in the adaptation of plants to stresses.
Distinct mutations throughout the viral genomes have been implicated in the adaptation of viruses to a mammalian host (Table 4, Appendix; and Table 5, Appendix).
CaMKII has also been implicated in muscle adaptation through phosphorylation of HDAC5 leading to MyoD/MEF2-driven differentiation of muscle cells [ 49].
For example, introgression has been implicated in the adaptation of modern humans [ 1] and is of concern to conservation biologists due to loss of integrity of wild bird and mammal populations [ 2, 3].
Another unconventional myosin, XVa, which is required for normal growth of hair cell stereocilia, has been implicated in fast adaptation based on a study of P1-P4 shaker 2 mice (that have no functional myosin-XVa) [ 55].
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