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These regions are less conserved than the orthosteric binding site but have to date not been implicated in activation of adrenoceptors.
Calpains have been implicated in activation of ER-localized caspase-4 in human cells [ 10].
Deficiency of vitamin D (25-hydroxycholecalciferol) has long been implicated in activation of tuberculosis (TB) (1 ).
Extrinsic influences have also been implicated in activation of the SNB.
PKA signaling has also been implicated in activation of metabolic flux through the glycolytic pathway.
NAC family transcription factors have been implicated in activation of ERD1 expression [ 15] and are predominantly induced by abiotic stress in guard cells [ 16].
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Interestingly, S125 and T127 in this loop were identified as sites of phosphorylation of Pellino1 by IRAK1 and IRAK4, although in this case Pellino1 phosphorylation was implicated in activation of the E3 ligase activity.
Intracellular signaling intermediate STAT1 mediates many effects of IFN-gamma and is implicated in activation of T-bet, a master regulator of Th1 differentiation.
The second p300 region of protein interactions is more proximal to the C-terminus and is implicated in activation of transcription.
In view of this, H2O2 was observed to be implicated in activation of GA synthesis and signaling [ 63].
AATYK tyrosine kinases may also be involved in production of AMPs, since they were implicated in activation of the apoptosis-associated JNK signaling pathway in vertebrates [ 22, 23].
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