Sentence examples for been implicated in abnormal from inspiring English sources

Since Bcl-3 has been implicated in abnormal cell survival we next asked if Bcl-3 is required for the survival of HCT116 cancer cells.

In various lymphoma patients, the V (D) J recombination machinery has been implicated in abnormal interchromosomal joining.

Hypoxia and HIF-1 have been implicated in abnormal collagen I deposition that results in increased cross-linking and stiffness.

Cells of the adaptive immune system, including T cells and B cells, have been implicated in abnormal immune responses in RA and are targeted by non-specific immunosuppressive therapy.

Activation of the RAA axis has been implicated in abnormal regulation of cerebral perfusion in the setting of hypertension and HF, often resulting in a righward shift of cerebral perfusion autoregulation towards higher blood pressures and increasing brain susceptibility to ischemia (Saavedra et al 2006).

Glycogen synthase kinase-3β (GSK-3β) is implicated in abnormal hyperphosphorylation of tau protein and its inhibitors are expected to be a promising therapeutic agents for the treatment of Alzheimer's disease.

In fact, its deficiency was implicated in abnormal Ca2+ regulation [48], while its mutations lead to increased Ca2+ permeability and apoptosis in vascular smooth muscle cells of Syrian hamster [49].

A similar observation was reported in white and black spruce somatic embryogenesis where increases in ethylene signaling were implicated in abnormal embryo development [ 39, 40].

The latter has been implicated in the abnormal vascular responsiveness to endothelin-1 and angiotensin II in diabetic-hypertensive rats.

Interleukin-10 (IL-10), although traditionally considered an anti-inflammatory cytokine, has also been implicated in promoting abnormal angiogenesis in the eye and in the pathobiology of autoimmune diseases such as lupus and encephalomyelitis.

Some kinases and phosphatases have been implicated in the abnormal hyperphosphorylation of tau [ 7].