Sentence examples for been implicated in aberrant from inspiring English sources
Survivin has been implicated in aberrant cell survival exhibited by tumorigenic cells [ 24].
Such dysregulation or posttranscriptional modifications of histones in chromatin, including histone lysine methylation, have been implicated in aberrant gene regulation associated with the pathology of diabetes and its complications, and genome-wide studies have shown cell-specific changes in histone methylation under diabetic conditions (35).
The NTF and CTF of PS-1 form a heterodimer that is normally incorporated into a gamma-secretase complex whose aberrant function in some forms of familial Alzheimer's disease is implicated in aberrant APP cleavage and over-production of toxic Aβ42 or an increased ratio of Aβ42 to Aβ40 [25].
Of note, mutations in PSMB8 (β5i) were implicated in aberrant immunoproteasome assembly and function causing human disorders linked to an auto-inflammatory pathogenesis [ 15].
The third sub-network (p = 3.40 × 10−12) is centered on c-Myc (Additional file 2: Figure S5C), and appears to be related to ephrin signaling, which is implicated in aberrant synaptic function [ 69].
In keeping with their key role in regulating the cell cycle, 14-3-3 proteins have been implicated in cancer (34); aberrant 14-3-3 14-3-3 14-3-3have also been linteractionshaveer's disealso(39) and diabeens (40).
Most medulloblastomas are thought to originate from cerebellar granule neuron precursors (CGNPs) [ 4], and several signaling pathways have been implicated in medulloblastoma formation including aberrant activation of WNT, sonic hedgehog (Shh), and epidermal growth factor receptor (EGFR) signaling cascades.
Furthermore, gap junctions on satellite cells surrounding the somata of sensory neurons have also been implicated in the spread of aberrant excitation within the DRG (Zhang et al., 2009).
Estrogens have been implicated in the promotion of aberrant prostate growth (Farnsworth 1999) and do not necessarily always work through indirect inhibition of androgen pathways (Harkonen and Makela 2004).
They show wide species variations and their aberrant expression has been implicated in a number of keratinizing disorders.
EGFR is an important signalling protein, and aberrant signalling has been implicated in the pathogenesis of several cancer types, including prostate cancer (see [37], [57]).
