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APOE has been implicated in Aβ clearance.
The phagocytotic action of both microglia and blood-derived macrophages has been implicated in Aβ clearance [38].
Nevertheless these findings do not exclude a central role for the amyloid cascade [5] in pathogenesis, and indeed, both processes highlighted by our analysis have been implicated in Aβ clearance in the brain [40] though further work is required to determine whether the risk these processes confer is mediated solely or in part through Aβ and whether they impact on risk via other mechanisms.
Cell-surface HSPGs have been implicated in Aβ uptake and cytotoxicity [ 17, 28, 48].
Moreover, autophagy has been implicated in Aβ metabolism and is therefore a potential therapeutic target in AD treatment.
The low density lipoprotein receptor-related protein 1 (LRP-1) and P-glycoprotein (P-gp) have been implicated in Aβ efflux [ 17, 18].
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