Sentence examples for been implicated both as from inspiring English sources

Aromatic amino acids have been implicated both as preferred carbon sources and also regulators of quinolone signaling and biofilm formation for Pseudomonas aeruginosa in CF sputum [26], [27].

For example, tetraspanins CD9 and CD82 have been implicated both as promoters of junctional organisation (Refs 118, 119) and as suppressors of tumour cell motility (Refs 120, 121).

GDF15 has been implicated both as a promoter and inhibitor of tumour growth (Tan et al, 2000; Baek et al, 2001; Levy and Hill, 2006; Abd El-Aziz et al, 2007; Johnen et al, 2007).

We also observed that PTZ exposure led to increased expression of pyya, a close relative of NPY, which has been implicated both as an endogenous inhibitor of epileptic seizures (Baraban et al., 1997) and as a neuroprotective component of the endocrine response to stress and mood disorders, mediating anxiolytic effects on neuronal targets within the mammalian CNS (Heilig, 2004; Thorsell, 2010).

Powdered formula has also been implicated both epidemiologically and microbiologically as a vehicle in several cases of E. sakazakii disease in infants (1, 3, 9, 10, 13 ).

Intracellular ATP levels have been implicated both in vitro and in vivo as a determinant of the mechanism of cell death.

Voltage-gated Kv1.5 and Kv2.1/9.3 channels have both been implicated (2– 32 32), as have voltage-independent, two-pore domain TASK channels (12, 38).

These studies have led to the idea that miRNAs may have a promising therapeutic aspect, since miRNAs have been implicated as both the active agent promoting regeneration, and as the regulatory mediator helping to uncover downstream targets and transcription factors involved in regeneration.

Notch has been implicated as both an oncogene or a tumor suppressor depending on the cell context47,48.

Anger has been implicated as both a mediating (Betancourt and Blair, 1992; Dalton et al. 1998; Rebellon et al. 2012), and moderating (Pond et al. 2012; Sprague et al. 2011) factor for aggression and aggressive behavior.

Since its identification as a component of the RNA polymerase II holoenzyme, Cdk8 has been implicated as both a positive and negative regulator of transcription.