ADPKD results from mutations in the polycystin genes PKD1 and PKD2/TRPP2 and mutations in their respective polycystin proteins, Polycystin 1 (PC1) and Polycystin 2 (PC2), both of which have been implicated as significant regulators of intracellular Ca2+ in renal tubules [4].
In mammalian cells, the tumour suppressor protein, p53 has long been implicated as significant in a cell's ability to either arrest cell cycle progression or to invoke apoptotic cell death.
A large number of biological processes were implicated as significant, including the nucleus accumbens development (Q = 6.31 × 10−7), nose development (Q = 4.52 × 10−6) and neurotransmitter transport (Q = 1.27 × 10−2) (see Table S4 ).
By extension, the psychologists who are members of the association are implicated as well.
Many studies have identified that the SphK isoform is responsible for the formation and release of S1P, and the production of S1P by SphK2 has been implicated as a significant regulator of cell proliferation33,35.
A number of cellular factors have been implicated as playing significant roles in regulating hTERT gene expression, among which are the proto-oncogene Sp1/Sp3, c-myc, Ets2 transcription factor (Wu et al., 1999; Kyo et al., 2000; Xu et al., 2008; Horn et al., 2013; Huang et al., 2013; Borah et al., 2015; Cheng et al., 2015), and the Smad3 repressor (Hu et al., 2006; Li et al., 2006).
"This has been demonstrated in only a few species so far, and has been implicated as a significant driver for human evolution," Krützen said.
Bovine spongiform encephalopathy (BSE) is a prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk.
Matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) have been implicated as playing significant roles in enabling invasiveness and metastasis of breast cancer [ 31, 39].
Beer, presumably because of the malting process, contains volatile nitrosamines and has been implicated as a significant contributor to total dietary exposure of nitrosamines [ 26].
