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In this regard, inhibition of RNA Polymerase II has been implicated as resulting in activation of the p53 tumor suppressor [ 59, 60], which is known to induce tumor regression [ 61].
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Altered distribution due to endothelial dysfunction and capillary leak [ 17], an iatrogenic fluid resuscitation-related increase in extravascular volume with dilution of Ig [ 64, 75], decreased production and/or increased consumption may be implicated, as could alterations in FcRn activity resulting in impaired recycling [ 76].
By extension, the psychologists who are members of the association are implicated as well.
Endotoxemia-induced toxicity is characterized by injury to various organs, including liver, kidney and the brain, and it has been implicated as a contributing factor to bacterial infection resulting in sepsis, which is one of the major causes of morbidity and mortality in intensive care units [ 2].
In environmental exposures, both pesticides and metals have been implicated as risk factors for PD, based on results from some epidemiologic studies (both metals and pesticides) as well as from experimental models (pesticides).
Tobacco exposure has been implicated as a risk factor for decreased bone density, which might result in osteoporosis.
Oxidative stress generated as a result of mitochondrial dysfunction has been implicated as an important factor in the etiology of Parkinson's disease.
Endothelial nitric oxide synthase (eNOS) polymorphisms have been implicated as risk factors for erectile dysfunction (ED), but the results of genetic association studies are inconclusive.
MMPs have been implicated as a crucial target in GBM cell invasion and as a result have been the focus for therapeutic development (Furnari et al., 2007).
As a result of their warming effects when relatively thin, cirrus clouds have been implicated as a potential partial cause of global warming.
Previous trauma or surgery has been implicated as predisposing factors.
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