Chronic nuclear STAT activation and/or JAK activation [ 20, 21] have been implicated as a predisposing event in a variety of tumour types indicating that pathway dynamics have significant impact on cell behaviour.
Rapid reduction of immunosuppressive therapy such as steroids has been implicated as a predisposing factor for the development of PCP in HIV-negative patients [ 11, 17, 23, 24].
A polymorphism in ER mannosidase I, an enzyme involved in the ERAD pathway, has recently been implicated as a genetic modifier predisposing to infantile disease (Pan et al., 2009).
These clouds have been implicated as possible harbingers of permanent changes in the upper atmosphere.
Both actomyosin cross-bridges and tendons have been implicated as important sites of energy storage [157,213].
On the contrary, the gamma nail has been implicated in predisposing to secondary femoral fractures, although this seems to be rectified by newer techniques and nail designs.
Such uses have long been implicated for Neandertals as well.
Cigarette smoking is a major risk factor, but several predisposing genetic factors have also been implicated in the pathogenesis of COPD (Hersh et al., 2006; Repapi et al., 2010).
Loss of imprinting has been implicated in a number of congenital syndromes, some of which, such as Beckwith Wiedemann syndrome, predispose towards certain childhood cancers (DeBaun and Tucker, 1998).
