E-cadherin, the primary epithelial adherens junction protein, has been implicated as playing a critical role in nucleating formation of adherens junctions, tight junctions, and desmosomes.
Human papillomavirus (HPV) has been implicated as playing a causal role in Barrett's esophagus, the metaplastic precursor to esophageal adenocarcinomas (EAC) and gastro-esophageal junction adenocarcinomas (GEJACs).
Collagenase has been implicated as playing an important role in the connective tissue destruction that is a major feature of rheumatoid arthritis.
Neuroblastoma is the most common solid tumor of infancy, and mutations in several genes have been implicated as playing a role in tumor development.
The phenotype of some of the commonly reported premonitory symptoms such as yawning, mood change and sleep disturbance suggest the involvement of brainstem and hypothalamic structures, including dopaminergic nuclei and such nuclei have already been implicated as playing a role in trigeminocervical nociception [22].
A number of cellular factors have been implicated as playing significant roles in regulating hTERT gene expression, among which are the proto-oncogene Sp1/Sp3, c-myc, Ets2 transcription factor (Wu et al., 1999; Kyo et al., 2000; Xu et al., 2008; Horn et al., 2013; Huang et al., 2013; Borah et al., 2015; Cheng et al., 2015), and the Smad3 repressor (Hu et al., 2006; Li et al., 2006).
Reactive oxygen species (ROS) and matrix metalloproteinases (MMPs) are implicated as playing a major role in the development of cardiac fibrosis.
Further, many miRs, including miR-24-2, are implicated as playing a role in cell proliferation and apoptosis, but their specific target genes and the pathways contributing to them remain unexplored.
Ill health undoubtedly played a role, but there is reason to think that the feeling of being watched as he worked, of no longer being alone in his room, was implicated as well.
Another cytoplasmic PTK, BRK, has recently been implicated as possibly playing a role in breast cancer.
