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Bone morphogenetic protein-7 (BMP-7, OP-1) is a secreted growth factor that is predominantly known for its osteoinductive properties, though it has also been implicated as having a role in mammalian kidney development.
Triclosan has been implicated as having a hormone-altering effect in animal studies.
Alternatively, the KCNK two-pore potassium channels identified as being central to eliciting tingle [11] have also been implicated as having a role in anesthesia [11], [42].
Meg3/Gtl2 is the founding member of a much larger imprinted gene region that has been implicated as having parent of origin effects in three mammalian species.
Both SPT4 and SPT5 are required for efficient transcription elongation and have been implicated as having roles in coupling transcription and splicing [55].
Integrins are a family of cell adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions [1], [2], [3] that also have been implicated as having a role in contributing to mammalian sperm-egg interactions.
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Detoxification of cisplatin includes gluthione conjugation, and glutathione S-transferase (GSTπ) has been implicated, as have two members of the multidrug resistance related protein family, MRP1 and MRP3, which are required to transport conjugated xenobiotics [ 21].
NIP45 is implicated as having a function in gene regulation [27].
Interestingly, the βNAC subunit was implicated as having apoptosis-suppressing activity at the mitochondria in Caenorhabditis elegans.
However, the validated targets were significantly enriched for factors localizing to the nucleus (2.2-fold more than expected by chance alone, P = 0.0002), and such factors are implicated as having a direct role in epigenetic gene silencing.
Growth inhibitory effects of cytokines have been implicated as well.
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