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Chemokines and their receptors have been implicated as functional mediators of immunopathology of autoimmune neuroinflammatory diseases [ 22, 23].
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Also, altered glutamatergic neurotransmission has been implicated as a functional substrate for psychotic and cognitive symptoms in schizophrenia [ 7], in addition to the classical dopamine hypothesis [ 8].
More recently, BAFF has been implicated as a functional high-affinity ligand for the Nogo-66 receptor (NgR) on astrocytes and microglia, where engagement by BAFF is involved in the pathogenesis of several autoimmune CNS diseases.
For older adults without diabetes, cognitive functioning has been implicated as a predictor of functional disability for older adults [ 3, 15- 21] and those with mild to severe cognitive impairment [ 22, 23].
Self-perceptions of aging have been implicated as independent predictors of functional disability and mortality in older adults.
Sarcopenia in the larger striated muscle groups has been implicated as the cause of functional decline and decompensation and is suspected in smaller striated muscles, such as those found in the head and neck (Robbins et al 2005).
For older adults without diabetes, cognitive functioning has been implicated as a predictor of death and functional disability for older adults and those with mild to severe cognitive impairment.
Two flavan 4-ols, luteoforol and apiforol have been implicated as precursors of phlobaphene pigments that accumulate in maize genotypes carrying functional p1 or p2 genes.
Non-functional splice alternatives of FLVCR1 have been implicated as a cause of a congenital red cell aplasia, Diamond Blackfan anemia 454.
A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated as a moderating factor in the relationship between childhood maltreatment and antisocial behaviors.
These clouds have been implicated as possible harbingers of permanent changes in the upper atmosphere.
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