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PFOS, PFOA, PCBs and phthalates have all been implicated as endocrine disruptors and have been linked to other reproductive outcomes.
Fe-TAML catalyst processes also degrade organophosphorus pesticides as well as their toxic degradation intermediates, some of which have been implicated as endocrine disruptors, says Horwitz.
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Several compounds to which the general U.S. population is regularly exposed have been implicated as affecting endocrine function or development.
Upregulation of the AKT/mTOR pathway has been implicated as one mechanism behind endocrine resistance.
Indeed, aberrant PI3K signaling has been implicated as a potential mechanism of endocrine resistance, with upregulation of AKT signaling and acquired sensitivity to mTOR inhibition.
These ortho-substituted PCB congeners and their hydroxylated metabolites are endocrine disruptors and have been implicated as developmental neurotoxicants by mechanisms involving altered Ca2+ signaling, interference with thyroid hormone signaling, and decreased dopamine content.
Organizational endocrine effects on physiology have been implicated as a developmental switch that leads to differences among social insect castes (West Eberhard 1987 19966).
Sel1h has been implicated as a Notch inhibitor in exocrine [ 34] and endocrine replication [ 35] and modifies the expression of genes involved in cell-matrix interactions and in the cell cycle [ 36].
Endocrine-disrupting chemicals have thus been implicated as factors in the human obesity and diabetes epidemics in developed countries as well as in developing countries.
Previous trauma or surgery has been implicated as predisposing factors.
Sugary beverages have been implicated as contributors to childhood obesity.
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