Sentence examples for been implicated as critical from inspiring English sources
The transcriptional enhancers Edelta and Ealpha have been implicated as critical regulators that, in conjunction with other cis-acting elements, confer region-specific and developmental-stage-specific changes in gene segment accessibility within TCR alpha/delta locus chromatin.
Because NO and its derivatives have been implicated as critical mediators of beta-cell destruction in IDDM, we conclude that well regulated insulinoma cell lines engineered for MnSOD overexpression may be an attractive alternative to isolated islets as vehicles for insulin replacement in autoimmune diabetes.
IRF family members have been implicated as critical transcription factors that function in cell growth regulation and hematopoietic differentiation [14].
Interferon regulatory factor (IRF) family members have been implicated as critical transcription factors that function in immune response, hematopoietic differentiation and cell growth regulation.
The core epitope for this mAb has been crudely defined as N671W672F673D674I675T676 (HXB2 numbering), though W680 has been implicated as critical to 4E10 binding in several studies [12], [21], [22], [23].
Antibodies, CD8+ T cells, CD4+ T cells, IFN-γ, IL-12 and nitric oxide (NO) have all been implicated as critical effectors in protection against pre-erythrocytic stage malaria [5].
Landmarks are critically important reference points for orienting and understanding relative location (but see Montello, 2017) and intersections are implicated as critical locations where decisions are made regarding whether to continue forward or turn (Golledge, 1999; Klippel, 2003).
MYBs are implicated as critical regulators of vascular differentiation and phenylpropanoid metabolism in plants, including the tree genera Picea, Pinus, Eucalyptus and Populus [ 45- 48].
Based on the influence of site-specific modifications, the N1 of A38 was implicated as critical to catalysis, and a reasonable model of a protonated A38 acting as general acid was developed.
We next examined the gene content of the replicated hub genes demonstrating grade-dependent differences in network connectivity, and found that in all but one case (DHRS2), these hub genes have all been previously characterized in expression studies of breast cancer, with many being implicated as critical regulators or markers of metastatic potential and tumor progression (Table 1).
Rapid MAPK phosphorylation has been implicated as a critical step in estrogen's effects on neuronal activity, gene transcription and neuroprotection.
