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Elevated lipids, inflammation and infection have each been implicated as additional mechanisms contributing to instability of vulnerable plaques.
Animal confinement gases, particularly ammonia and hydrogen sulfide, have been implicated as additional sources of respiratory irritants.
Furthermore, enzymes of the energy metabolism, the Bcl-2-family member Bmf and production of reactive oxygen species have been implicated as additional factors in programmed necrosis [ 4].
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By extension, the psychologists who are members of the association are implicated as well.
The mechanism by which the microspheres lodge in the vasculature and the corresponding heterogeneity of radiation dose has been implicated as an additional challenge in radioembolisation dosimetry.
Wnt inhibition has been implicated as an additional signal, specifically acting to gate different responses to different levels of FGF [30], [66], [68].
Recently, VEGF, which, as noted above, is a potent vascular permeability and angiogenic factor, has been implicated as an additional explanatory factor that determines MR signal enhancement although the relationship between MRI enhancement and tissue VEGF expression is not straightforward.
Comparison with published data revealed that 200 upregulated and 66 downregulated genes had not previously been implicated as Nodal target genes (see Additional file 1: Table S1 and Additional file 2: Figure S1).
Both of these factors have been implicated as potential causes of insulin resistance, thus suggesting an additional indirect mechanism of FA-induced insulin resistance (29).
Additional health measures such as body mass index have also been implicated as risk factors for depression [ 27].
Beside their allergenicity, the major HDM allergens possess additional activities: Der p 1 is a cysteine protease which has been implicated as a Th2 adjuvant in asthma (25).
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