Several transcription factors, including Sox9, FoxA2, HNF1β and HNF6, have been implicated as activators of neurogenin-3 expression (Jacquemin et al., 2000; Lee et al., 2001; Maestro et al., 2003; Lynn et al., 2007), whereas the inhibitory bHLH transcription factor Hes1 suppresses neurogenin-3 expression (Jensen et al., 2000b; Lee et al., 2001).
Snail, Twist, and FOXC2 have been implicated as transcriptional activators for genes like CDK inhibitor p15INK4b, Akt2 and plasminogen activator inhibitor type I, respectively.
Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs).
DT-diaphorase, a cytosolic reductase, has been implicated as an activator of chemotherapeutic prodrugs and a detoxifier of certain potentially carcinogenic xenobiotics.
Moreover, it has been implicated as an upstream activator of Akt and may thus contribute to fibrogenesis [24], [25], [26].
In addition, pIX has been implicated as a transcriptional activator of several viral and cellular TATA-containing promoters, including adenoviral E1A, E4, and major late promoters [13].
Bv_iogq is the only BvMYB in clade C13 (S7) clustering together with landmark MYBs having been implicated as flavonol- and phlobaphene-specific activators of flavonoid biosynthesis during plant development.
Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more malignant tumor phenotype.
Since TACE is one of the major activators of TNF-α, TACE-inhibition has been implicated as a promising anti-inflammatory approach [17], [24].
Wnt4 and receptor activator of NF-κB ligand (RANKL) have been implicated as important paracrine mediators of progesterone function.
ERRγ has been shown to be a transcriptional activator of DAX-1, and DAX-1 has been implicated as having an antagonistic effect to Sry in mammals [ 43].
